LOL all you need to pick up girls is confidence and an ability to say "hi" without sounding like a retard. There are no pickup lines - however, you should be able to say any pickup line you want and have her laugh at it. Getting kisses at nightclubs is fun at first, but then you realize that those girls look quite different in the daylight.
Let's take this profession. Some of you say it's "nerdy ass internet marketing" ok, but have you realized you can fascinate chicks with this crap? For example, let's say I'm promoting Dating offers on Facebook. Girls are already obsessed with Facebook, so they're interested from the get go. You can tease them by saying you know all about human psychology and social relations (the female domain) because you know how to convince people to sign up for a fucking dating offer in less than 135 characters. You can tell her girls are way too predictable...from then on she'll be trying to prove to you that she's unique. That will be your first inside joke. Try it at a house party. If she's super skinny, talk to her about berries. (This shit works.) Trust me, it's way more exciting for girls to listen to this kind of crap than to hear yet another spiel of "I'm a first year analyst at Accenture" or the dreaded "I'm about to make Associate at JP."
If you want normal girls, avoid nightclubs. Stick to chatting up girls at house parties (where they trust you already cause you were probably invited) or at normal places like bookstores/grocery stores. And fucking Starbucks, of course.
Edit: and for those of you who are still, in this day and age of 'peacocking' and 'the mystery method' adamant about picking up chicks in nightclubs west of Berlin, here's a strategy that never fails. Get to a position where you can see everyone dancing from up above, so you can pick a good target. Hot girls will never be by themselves, so expect a pair of girls or maybe even a gaggle of 4. This way, you can save time by not having to push through the crowd. Once you have your target, look around them. You will notice at least 4 frustrated chumps orbiting the girls, high 5ing each other, maybe some will have ed hardy shirts. Ok, this is the crucial part. In one swift motion, you're going to eliminate teh douche threat and befriend the girls. Everything happens in about 8 seconds. You confidently stride into the middle of this clusterfuck, put your arm around the guy (you all should be comfortable with this), nod your head and smile to make sure he doesn't panic, and in 1-2 seconds go up to the girls and say "hey girls I want you to meet my friend, this is the fucking coolest guy alive, have you met him?" At this point, the guy will be so fucking ecstatic that he will forget to call you a homo, meanwhile you go for the HOTTER girl yourself as the UGLIER girl gets caught up with that idiot.
(This shit works in Toronto, but I hate clubs and only go for pure entertainment, like a human zoo)