the problem with using these supplements is that your body starts requiring them every time you're doing whatever physical activity you take them for, which makes any type of competition training less realistic.
for your regular gym goer that's doing a normal 5-day split type routine and then going home, it's fine to take supplements if it helps you, even if it's a placebo effect.
for people that take it seriously as a hobby or for competition, it makes no sense to use supplements that would be considered "performance enhancing" if you're trying to gauge your strength and your natural athletic abilities if you're relying on something to get through your training.
bottom line though is i think it's foolish to say jack3d is going to pose a serious threat to the majority of people that take it. think about how many people binge on cocaine and heroin and don't die. everything effects people differently.