I drink quite a lot and get pretty gnarly hang overs, so I've done quite a bit of research on anit-hangover remedies. I tend to find a lot of random wild things similar to this thread, but I've tried a variety of them and it really only helps a bit (for me).
Obviously, tons of water and gatoraide help, but who the hell wants to drink a litter of water after every beer? And trying to chug a gallon of water right before bed isn't really ideal, it just doesn't settle right. Charcoal, vitamins, ani-hangover pills -never did much that I was aware of and weed just intensifies everything in my head. (And it won't kill you instantly, but you guys know that acetaphetamine + alcohols is like the #1 liver killer right?)
I've noticed that my hangovers over the last few years have become progressively worse too, but then I realized it was because I became addicted to scotch. Scotch seriously fucks my world up the next day. 400ml, about 4.5 shots, of Scotch is much harder on me than 8 beers. A good friend of mine drinks whiskey waters (like 1/3 whiskey, 2/3 water) and claims to never get hung over because of it. (I think they are a bit gross)
I've heard that the absolute surefire method is the IV Drip and I actually called the one in Vegas once, but they charge like $120 DURING business hours. I would have done it at the time, but they only had their "emergency after hours" service which cost over $300. Ugh, missed a nice dinner that night.
The only real accessible cure that works for me is "hair of the dog", but I have to use it as a tool to feel better and then eat/hydrate. I have to be careful though, it's not hard to drink it all away then wake up again feeling 2X worse.
Hangovers are the reason I drink quite a bit less now. No sob story, I just fucking love getting ma drink on.